Over the last 30 years, the support for decision making in drug development projects and portfolios has remained practically the same. Today, new rapid technologies for modeling and simulation are finally available. These technologies enable you to evaluate more development options than ever before. You no longer need to hide uncertainty behind estimated point values. Instead, you can deal with uncertainty in a productive way and use the insights gained. Doing so you mitigate risks and find new promising opportunities. You will be more creative, pro-active and rapid in your work. This may be worth billions.